Jake is just 3 years old. When he was 4 months old , he was diagnosed with a very rare genetic mutation called X-Linked Hyper IgM. Jake's condition means he has no working immune system and is at constant high risk , of infection.

Case studies have shown that this condition without a transplant has a life expectancy of under 25yrs.So a bone marrow transplant is currently the only cure.

If you were to meet Jake, you wouldn't think there was anything wrong with him, you would probably notice his walking is off a little and he has squints in both eyes, he's eating like a horse because of the steroids, laughing and playing and is being so very brave.

But we need to watch him like a hawk, and all his drinks need to be boiled. He cannot go back to nursery, cannot play with other kids, go swimming, visit a farm or do the things most kids his age do.

He thinks the MRI scanner is a doughnut machine. He thinks he has dirty bugs in his head. He thinks the line in his chest are wiggly worms.

He doesn't fully understand why he cannot go back to nursery with his friends, he just says... I don't want my friends to get my dirty bugs :(

Jake also has CTPS 1. (CTP synthase type 1), this means his body doesn't have T cells to fight off infections. His cells are dividing and multiplying 100 times over than they should be doing , they are working overtime and bouncing out of control.

One morning a few weeks ago, Jake woke up, got out of bed, and fell over. We thought nothing of it. He then started falling over quite a lot and toddling instead of walking. We took him to the doctors who sent us to the hospital.

There was concern at the hospital about his mobility and why to he was struggling to walk all of a sudden and his eyes had got worse, so they did a MRI scan, and took bloods.

MRI scan revealed three lesions ( tumors ) on his brain, two at the back of his head, and one huge one in his forehead. They said he had picked up the EBV virus which he couldn't fight off because of his IgM and this virus had attacked his brain.

Jake had emergency brain surgery to release the pressure of the tumors on his brain, followed by a 2nd surgery to fit a chest line to administer drugs through and leave in ready for his transplant.

Jake is now being given Rhituximab Cancer Treating steroids in an attempt to get rid of the virus which will also hopefully kill the tumors. He has also had his first batch of donated TCells.

Jake is now waiting to have a bone marrow transplant at Manchester Royal Children's hospital. In the meantime he will continue his treatments and it means endless trips to the hospital every week.

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I have set up this fund to ease the worry of finances for mummy and daddy , Mummy cannot go back to work now, as she is Jake's full time carer, and with only one low wage coming in, things are already hard enough for them, and with a little help and support, it will make life a little easier.

I know times are hard for everyone and we really do appreciate anything you can give. So please, give what you can no matter how small. Thank you Angela ( Jake's Nan )