Clearing the Brain
Protein Clearance in Neurodegenerative Disease

Monday 30 October,
Venue:  Woborn House Conference Centre, Tavistock Square

The symposium will be live streamed on  30 October and a live stream link will be posted on the day of the symposium.

The URL for the live stream is...

https://www.youtube.com/watch?v=2-8Q6klVMCk

Contributions are invited to support the symposium and student bursaries.

RSVP at: https://www.eventbrite.com/e/clearing-the-brain-protein-clearance-in-neurodegenerative-disease-tickets-37809893409

PROGRAMME

09:30   Registration, Tea / Coffee & Networking

10:15   Welcome: John Hardy

Session 1: Perivascular Clearance

Chairs:  Cheryl Hawkes (Open University) & Tammaryn Lashley (UCL)

10:30   Roy Weller – University of Southampton
             Pathology of cerebral amyloid angiopathy (CAA)

 11:00   Roxana Carare – University of Southampton                         Testing the hypothesis that CAA results from a failure of   
              intramural periarterial drainage of fluid

11:40   Henrik Zetterberg – University College London                      Blood-based biomarkers for neuronal injury: an update on
             promising and less promising candidates

12:00                         Lunch Break       

Session 2: Glymphatics

Chairs:  Elizabeth Fisher (UCL) & Selina Wray (UCL)

13:00   Maiken Nedergaard – University of Copenhagen
             The glymphatic system: Update and future perspectives

13:40   Jeffrey Iliff – Oregon Health and Science University
             Evidence for the role of glymphatic dysfunction in human
             Alzheimer’s disease

14:20   Mark Lythgoe – University College London
             Untangling Alzheimer’s: Imaging brain clearance

14:40                          Tea / Coffee Break & Poster Session

Session 3: Brain Lymphatics

Chairs: Helene Plun-Favreau (UCL) & Tom Hawkins (UCL)

15:10   David Attwell – University College London
             Amyloid beta decreases brain energy supply by activating
             pericytes to constrict capillaries

15:30   Jason Rihel – University College London
             A novel lymphatic cell in the zebrafish meninges

15:50   Jonathan Kipnis – University of Virginia School of Medicine             Meningeal lymphatic angle of neurological disorders

16:30                              Short Comfort Break

16:35   Panel discussion with Roxana Carare, Roy Weller, Jeffrey Iliff,
             Maiken Nedergaard & Jonathan Kipnis.  Chaired by Mark Lythgoe.

17:20   Closing remarks

17:30   Drinks Reception & Networking