Orthopaedic Research UK (ORUK) aims to improve the lives of millions of adults and children affected by bone and joint disease through funding high quality research, training and education. Our research projects promote collaboration between surgeons, scientists and engineers. They have helped develop new artificial limbs and joints, led to better pain relief, increased insights into conditions such as bone tumours, arthritis and osteoporosis and improved the treatment of sporting and trauma injuries. We are one of the most significant funders of orthopaedic research in the UK, but much more needs to be done to achieve our ultimate vision of eliminating bone and joint disease.