Progressive Supranuclear Palsy (PSP) involves the progressive death of neurons (nerve endings) in the brain, mainly in the basal ganglia and brainstem, just above the nuclei (hence ‘Supranuclear' being a key part of its name).

The area affected in PSP controls balance, movement, vision (particularly upgaze and downgaze) speech and the ability to swallow, hence the main symptoms, some of which may not appear or progress at all or until later in the disease. Other symptoms, including behavioural changes and weight-loss, may appear.

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