Cancer is a significant clinical problem in Australia and across the world. It is critical to develop novel treatment strategies to improve the health outcome for patients.

Despite major improvements in therapies, at least 50% of patients with advanced melanoma still die of disease. Moreover, many patients will receive therapy with no benefit but risk serious side-effects. Improved therapies are needed if patient survival is to increase.

Oesophageal cancer is also a major health problem in Australia. For more than 50% of patients, their initial diagnosis is made when they already have advanced disease.

Pancreatic cancer is a deadly cancer with a five-year survival of ~11%. Cure is only possible with surgical resection, but only 20% of patients are operable. The remaining patients are locally advanced or metastatic and therefore incurable.