Xeroderma Pigmentosum (XP) is a very rare genetic condition characterised by an extreme sensitivity to ultraviolet radiation (UVR).

It affects less than 100 patients in the United Kingdom and equally low numbers around the world.

Patients with XP lack the DNA repair mechanism to repair damage caused to the skin by exposure to ultraviolet (UV) light.

The primary cause of exposure to UV is through exposure to daylight and this light is made up of two types of harmful rays that reach us. Long wave ultraviolet A (UVA) and medium wave ultraviolet B (UVB). 

UVR is present during all daylight hours, found in many types of artificial lighting and even lightning. Unless patients with XP are protected from UVR, their skin and eyes will be severely damaged and this can lead to skin cancer. XP patients are at a 10,000 fold increased risk of developing skin cancer than the general population and often this starts at a very young age.

About 30% of people with XP also develop neurological abnormalities which can range from learning difficulties, hearing loss and eye sight problems to loss of gross motor skills and mobility. 

There is no cure for XP, but much can be done to prevent and treat some of the problems it causes.

Protection from all sources of UVR is required, including total daylight avoidance via specialised clothing and sunscreens. A significant commitment to lifestyle changes is also required to mitigate against the risk of exposure and combat its effects. People with XP must also undergo frequent skin, eye and neurological examinations and have prompt removal of cancerous tissue.

My photographic career relies on my ability to manipulate light, and light is something which I love so much - yet for those affected by XP, it is an ever-present, serious problem, which can make everyday life extremely complex. Please help me, help them. No amount is too small - and I have no 'target' to reach, Teddington Trust is a small charity, and the money will be put to great use. Many thanks.