On the 2nd October 2016 Andrew Fleming lost his long fight against the rare Liver disease PSC (Primary Sclerosing Cholangitis).   Andrew was a loving husband, wonderful dad and adored by his four grandchildren.  He lived an active life and was a committed cyclist and logged many thousands of miles but he always had time for his family and friends.  

PSC is a a chronic liver disease whereby the bile ducts, which are the passages that carry bile from the liver to the intestines, become narrowed from inflammation and fibrosis. Over time, the scar tissue builds up and can block parts of the bile ducts completely. The blockages can occur in any part of the biliary tree: inside the liver itself (intrahepatic) or outside the liver (extrahepatic).

The narrowed or blocked bile ducts interrupt the flow of bile out of the liver, causing a variety of symptoms; ultimately leading to biliary cirrhosis, portal hypertension, and liver failure.

PSC occurs in twice as many men as women. The age at which most patients present is between 25 and 40 years, though the condition may be diagnosed at any age and has recently become recognized as an important cause of chronic liver disease in children