Myeloma, also known as multiple myeloma, is a blood cancer arising from plasma cells. At any one time there are around 17,500 people living with myeloma in the UK. It accounts for 15 per cent of blood cancers, and two per cent of all cancers. Myeloma mainly affects those over the age of 65, however it has been diagnosed in people as young as 20.
Myeloma develops when DNA is damaged during the development of a
plasma cell. This abnormal cell then starts to multiply and spread
within the bone marrow. The abnormal plasma cells release a large amount of a single type of antibody – known as paraprotein – which has no seful function.
Unlike many cancers, myeloma does not exist as a lump or tumour. Most of the medical problems related to myeloma are caused by the build-up of abnormal plasma cells in the bone marrow and the presence of the paraprotein in the body.
Myeloma affects multiple places in the body, which is why it is
referred to sometimes as ‘multiple’ myeloma. Myeloma affects where bone marrow is normally active in an adult, such as in the bones of the
spine, skull, pelvis, the rib cage, long bones of the arms and legs and
the areas around the shoulders and hips.