Support the Big Walk 2025 at University of Sheffield and help to advance ground-breaking research into neurological diseases including MS, MND, dementia, Parkinson’s and stroke.

One in six people, and one in four over the age of 80, will develop a significant neurological condition in their lifetimes. With your support, Sheffield can develop life-saving new treatments.

These degenerative conditions exact a devastating toll on patients and their families.

- Motor Neuron Disease gradually robs an individual of their ability to move, speak, swallow, and breathe independently.

- Parkinson's steadily erodes a patient's motor functions, leaving them trapped in a world of tremors, rigidity, and an increasing loss of control.

- Dementia strips someone of a lifetime of memories, making their loved ones unrecognisable.

- MS can take a person’s strength, causing physical and cognitive challenges that may affect their ability to work, maintain relationships, and enjoy everyday activities.

- Stroke suddenly changes a patient’s life, robbing them of the ability to perform daily tasks and enjoy life.

You’ll help to fund the first site nationally to develop experimental genetic therapies for dementia and MND, and the first to deliver a highly promising new stem cell treatment for MS. You’ll also fund research into new potential therapeutics for stroke, and speed up the development of personalised treatments for Parkinson’s, helping to slow - or even stop - how quickly the disease takes hold.

Your support could truly be a catalyst for transformative breakthroughs that could cure these devastating conditions in our lifetimes.

Globally, neurological conditions are becoming one of the greatest public health problems worldwide. These conditions are placing an increasingly heavy burden on national healthcare systems. For many of these diseases, numbers are rising. There are 55 million people living with dementia around the globe and as our population grows and ages, it is estimated that this number will rise to 139 million by 2050.

Despite decades of research, these diseases are notoriously difficult to treat, with treatments masking symptoms rather than curing the root cause of these devastating illnesses.

A new approach to tackling neurological diseases has been long-needed. And researchers in Sheffield are at the forefront of driving breakthroughs and bringing hope to millions at last.